Peter Quill is Star-Lord, the brash adventurer who, to save the universe from its greatest threats, joins forces with a quartet of disparate misfits--fan-favorite Rocket Raccoon, a tree-like humanoid named Groot, the enigmatic, expert fighter Gamora and the rough edged warrior Drax the Destroyer.
Caught red-handed by Titus, the Guardians are coerced into infiltrating a notorious gang of weapons dealers known as the Black Order.
Quill gets mixed up in a game of deceit when Gamora tries to pit her siblings, Nebula and Korath, against each other.
When Groot is infected by a super-evolved Venom Symbiote, Rocket must go to extreme measures to save his leafy friend.
Rocket is abducted and taken back to his home planet, Half World, where he gets caught up in a revolution of evolved former test subject animals.
The Guardians encounter a living planet that's fallen under the control of a revived Ronan.
The Guardians get caught up in a rivalry between The Collector and The Grandmaster.
The Guardians get caught up amongst the Inhuman Royal Family and must help save the City of Attilan from Ronan.
The Guardians find the Asgardian Destroyer Armor that leads to an epic battle pitting the Destroyer Armor against Drax the Destroyer.
Quill goes missing while following the Cryptocube's readings.
The Guardians must stop Ronan's plan to blow up the Kree Supreme Intelligence.
In search of the Cosmic Seed, the Guardians unexpectedly find themselves in Asgard where they must outwit Thor and Angela in order to discover the seed's origins.
Following a falling out with his father, Star-Lord finds a ship containing the A.I. Rora as he takes it off of Spartax with the Drax the Destroyer and Groot providing a diversion for the Spartax Royal Guards. Afterwards, the Guardians of the Galaxy have to deal with Lucy and Supergiant who are jilted that Star-Lord is the Prince of Sparta.
When Asgard attacks Spartax, Quill and the Guardians become caught in the middle trying to expose the deception behind the conflict.
The Guardians and Asgardians team up to rescue Quill from Thanos.
Gamora attempts to make amends for her past misdeeds only to find herself in a deadly trap set by Nebula, Ronan and the Grandmaster.
The Guardians pay the Inhumans a visit to learn more about the Cosmic Seed.
When the Guardians of the Galaxy's search for the Cosmic Seed continues on Earth, they are forced to confront Ronan the Accuser, Nebula, and Thanos.
The Guardians battle a Cosmic Seed supercharged Thanos, who takes control of the Earth and molds it into his personal planetary weapon of mass destruction.
The Guardians of the Galaxy discover that Yondu and four of his Ravagers have been impersonating them in order to con the unsuspecting victims of Floodworld where they unleash a hydrated Groom for them to fight and dehydrate while robbing their houses. When it comes to the latest heist, the rampaging Groom swallows Star-Lord and Yondu. While Star-Lord and Yondu work to get out of the Groom, the rest of the Guardians of the Galaxy and the Ravagers must work to subdue the Groom.
While trying to dispose of Thanos' asteroid, the Guardians discover it has been taken to a secure facility that belongs to the Avengers.
The Guardians and the Avengers team up to find out what powerful secrets lie inside Thanos' asteroid.
When Rocket and Drax wake up with absolutely no memory of the night before, the Guardians must piece together their adventures.
While the Guardians search for the missing sarcophagus, Groot finds a mysterious egg and does everything in his power to protect it.
When the Guardians are charged with escorting the young and rebellious Rigellian Princess Tana back home, Drax's hardened heart melts as he is reminded of his own daughter.
After being infused with incredible power from a Nova helmet, Gamora leads the Guardians and her sister Nebula on a mission to infiltrate the Believer flagship.
Quill and Gamora battle the High Evolutionary, his minion hybrids and a teleport-hijacking Nebula.
Cosmo goes undercover on the Believer flagship but loses his powers when his cover is blown.
When the Believer flagship embeds itself in Knowhere's brain, it causes a planetoid-wide telekinetic zombie outbreak.
When the cocoon opens and reveals a baby warlock inside, the Guardians have to step in to be a positive guiding force to keep his powers in check.
The Guardians discover Groot's homeworld, Planet X, has been overrun by Symbiotes who will stop at nothing to get Groot's restarted World Pod for themselves to conquer the galaxy.
As a comet covered in Symbiotes comes barreling towards Spartax, the Guardians must team up with Quill's sister Victoria to save the planet.
When the Symbiotes escape to Asgard and venomize Thor, Odin and the other Asgardians, it's up to the Guardians to save them, the World Tree and all of existence.
Captain Victoria contacts Star-Lord, telling him that there is an Earthling using the missing Nova Centurian helmet and that the Nova Corps have issued a bounty of 10,000,000 units. Rocket Raccoon and Groot head out and find the helmet in the possession of Sam Alexander. When the other Guardians of the Galaxy members catch up, they learn how his father Jesse used the helmet and didn't come home, causing Sam to search for his dad. Following Star-Lord's attempt to scare him straight at Starlin's Bar on Knowhere (with the help of Kraglin and the Ravagers with him), Nova follows a signal to Spartax. There he encounters Mantis, who says the Universal Believers' Patriarch will lead him to his father.
Now that Star-Lord knows that his father J'son is the Patriach of the Universal Believers and that Nova has freed him, the Nova News has issued a bounty of Nova. The Guardians of the Galaxy trace J'son's Elemental Blaster to the inside of a space whale, where a Xandarian ship is. When J'son and Mantis trap the Guardians of the Galaxy, they manipulate Nova into attacking the Guardians of the Galaxy as a way for Nova to find his long-lost father using the true Nova Centurian Helmets on board that don't have dire consequences.
Rhomann Dey and the Nova Corps catch up to the Guardians of the Galaxy at the time when they are pursuing J'son and the stolen Nova Centurian Helmet. Nova escapes and manages to make it back to Earth. Then he is attacked at his school by J'son, who discovered that he can't remove the helmet from Sam due to it being tied to his DNA. Following the Guardians of the Galaxy and Nova's fight with J'son at Sam's school, Sam finds that J'son knows where he lives and finds J'son confronting his mother and little sister Kaylen posing as a police officer. The Guardians of the Galaxy must help Sam keep his family safe from J'son.
Following the fight with J'son on Earth, the Guardians of the Galaxy work to find the stolen Nova Centurian Helmets. To have an anti-Nova Corps helmet weapon, the Guardians of the Galaxy plan to head to the planet Cindra in order to seek out the known weapon designer, Ja Kyee Lrurt. When they find her, she is a prisoner of her sentry robots. These robots only have the knowledge of war and want her to build a doomsday weapon that will take out their Ultroid opponents. Now the Guardians of the Galaxy must obtain a doomsday while dealing with the war between the Sentries and the Ultroids.
When the Guardians travel to Drax's home planet in hopes of summoning Warlock, they discover Xeron seeks to destroy Adam and Drax's homecoming, which becomes a fight to protect his friends.
Rocket and Warlock travel to Halfworld to try and re-evolve Rocket's family.
Gamora trains Warlock to be a strong and powerful warrior like herself, but when Gamora's lessons become too intense, Warlock clams up and is kidnapped by the Collector.
When Quill and Warlock are hunted by J'son and the Black Order, Quill teaches Warlock the importance of never letting himself slip into the path of evil.